The tomb of Yan Dong, the former head of the Six Horsemen Division in Chang'an, is hit by tomb robbers and the Xuanmao pearl, which was used to suppress the demon king, is stolen, leading to the rise of demons in Chang'an City and the unrest of the people. The Chief Steward, Eunuch Fish (Luo Jiaying), orders Ma San (Wu Mengda), Wang Zhuge (Jia Bing) and Lei Yan (Xu Dongdong) of the Six Horsemen Division to suppress the demons and hunt for the pearl, and to hatch a terrifying plot.

A year ago, Yan Chixia, alongside her family, killed the Fox Demon. Her younger sister Jiang Xue, however, was turned into a demon l, and under the intervention of the sect, becomes even more involved with Yan. The deep misunderstanding brought on by Chixia causes that he has become her mortal enemy. The two are separated by two generations of enmity against the monsters. Yan Chixia becomes one who exterminates demons, while Jiang Xue quietly transforms into a nine-tailed fox known as Shen Si Rou.