Hell Bent Wade is the victim of an attack in which is wife is killed and daughter kidnapped. A couple of decades later, he is a sheriff known only as the "mysterious rider," because of his nighttime prowls in search of cattle rustlers.

To get in the good graces of his rancher boss’s daughter, cowboy Single Shot captures a cattle raider but then gets kidnapped by his gang of thieves.

A mining engineer teams up with a crusty deputy sheriff to solve the mystery killings at an old mine where the owner's family waits for him to die, and where a valuable radium strike may have been made.

An Easterner Inherits a cattle ranch, only to discover that thousands of cattle have been stolen. He secretly signs on as a hired hand at his own ranch to discover who's stealing them.

Wanted by the law in New York, Dr. Steve Kells heads west and arrives in an area controlled by an outlaw gang known as the Border Legion. When the gang's boss is wounded, they kidnap Kells and force him to remove the bullet. Not allowed to leave and being a wanted man, he joins the gang. Now wanted as a gang member also, he nevertheless plans a raid that will lead the entire gang into a trap.

Knowing the railroad is coming, Carter is after the rancher's land. Bob and Chito return just in time to save Banker Stockton and his money from Carter's men. When Stockton then lends the ranchers money, Carter has them burned out. Bob knows Carter is responsible and when Carter's henchman Saunders is recognized, Bob goes into action.

Clint Belmet is a bit of a firebrand and is sentenced to at least 30 days in jail, but his partners, Bill Jackson and Jim Bridger talk a sympathetic Frenchwoman named Felice into telling the bumbling, drunken marshal that Clint had married her the previous night. Clint is released so he can accompany Felice on the wagon train heading west to California.

Marvin Hayden returns to find his ranch is about to be sold at auction and the Hayden Jorth feud still going strong. Carson wants the Hayden ranch and tries to kill Hayden. When he fails he kills Chick Jorth with a rock. As Hayden does not carry a gun and the two had argued earlier, Hayden is arrested for the murder. With Hayden in jail, his friends Chito, Ginger, and his Lawyer Gardner now go to work to find the murderer.

A once notorious gunfighter takes a respectable job on a ranch. "Nevada" is charged with protecting the ranch owner's pretty daughter, arousing the enmity of ranch foreman Clan Dillon, who is in love with the girl. The villainous foreman leaks a rumor of his rival's dark past to the sheriff, and the former outlaw is soon on the run again.

A wagon train heads west from Independence, Mo., along the Oregon Trail, led by proud cowboy Clint Belmet. On board are feisty young widow Nancy Wellington and her toddler, Sonny, as well as the older Abby Masters, who begins a romance with scout Jim Burch. Along the way, the wagon train battles Indians led by Kenneth Murdock, a trapper who doesn't welcome competition for Oregon's lucrative fur trade. Wagon Wheels is a 1934 remake of 1931's Fighting Caravans, using stock footage from the original.