All hell breaks loose in "El Barrio" of East Harlem, when the father of a young, light skinn Puerto Rican girl discovers she is dating a young African American man.

A dirty police sergeant and a drug kingpin try to clean up their own organization by murdering all the street snitches while attempting to frame it on two Lady Riders, who are trying to get revenge on the drug dealers that raped them. Meanwhile, a detective is on the trail of breaking down these dirty cops and drug dealers, and at the same time trying to stop the two Lady Riders from getting framed for murder.