Pursued by formidable Chinese assassins, young Kotaro and his dog run into No Name, a mysterious stranger who gets pulled into the chase. The unlikely companions form a bond over saving the dog from a poison attack, but chaos erupts when the assassins find Kotaro, and No Name must face his past before a horrible fate is met again.

Hissatsu Shigotonin 2022 is a continuation of the Hissatsu Shigotonin series. This was the SP released in 2022.

Kanzo Hattori, an apprentice Ninja, leaves his home town of Iga for his final training. He must go to the city of Edo (Tokyo), and the first person he meets shall be his master, whom he must protect with his life, whilst upholding the ninja code. Also while in Edo, Hattori must find out why their rivals, the Koga Ninjas, are flourishing while the Iga Ninjas are dying out. Hattori's master is Kenichi, a 9 year old boy. Kenichi is an introvert and not very popular boy, so he never plays with the other children from school. Kenichi also has a secret crush on a young lady called Midori, yet he's too shy to speak to her. Though as he watches Hattori trying his best, he too begins to try. Meanwhile, people are being found unconscious, their bodies completely unmarked. All the victims have a tattoo (the Koga Ninja crest) and are found with a throwing knife lying close by.

An epidemic is spreading through the towns of Edo – it spreads via people, and if you get the fever, your face will turn red like a demon, and then you will die. There is no cure in sight, and people’s anxiety is increasing.