One day Pop was out scavenging with Hana, and found a beautiful rose inside the Queen's garden. Curious, she picked the rose and brought it home. Unwittingly, that rose can cause all wishes to become true, whether good or bad. Good wishes will turn the rose white and bloom, while bad wishes will turn the rose black and wither. After a heated argument with her sister Doremi, Pop wishes that Doremi loses all her magic and be turned into a mouse. Hilarity ensues, as Doremi and the others try to put everything back to normal.

Three women – 27 year old Tokyo office worker Mire Yoshizuki, 22 year old fourth-year college student Sora Nagase, and 20 year old boyish, part-time Hiroshima okonomiyaki shop worker and freelancer Reika Kawatani – are drawn together by a magic gem.