Leading an expedition in Germany, Kougami unseals the resting place of one of the alchemists that created the Core Medals in an effort to retrieve a set of lost Medals. However, upon the seal being undone, millions of Cell Medals erupt into a tower while creating a magical barrier that causes parts of Japan to flip over. As the alchemist reveals her plans to become a new OOO, Eiji and his friends are thrown into the past and must find their way back home and stop the alchemist before she destroys the world!

The “Amazon Livestock Project,” a mysterious care facility, the Amazon extermination organization 4C (Competitive Creatures Control Center) pursuing Haruka Misuzawa . . . all come together in a tale of symbiosis and competition; the mortal combat between the carnivore and herbivore. And, finally, an end to the troubles and conflicts of the Riders, two beings confronting a fierce fate.

High school student Saya Toma lost her parents and younger brother in an airplane accident. Detective Akio Kondo came and told her "your family has a high possibility that they were killed by people who have spec." That was the first time she heard of "spec". 6 years later, Saya Toma, who has never forgotten what the Detective said, decides to become a detective. She returns to Japan after receiving training by the FBI in the United States. Saya Toma is assigned to work unsolved cases in the Public Security Bureau. Meanwhile, because of Satoshi Chii's scheme, Juichi Ninomae considers Saya Toma his parents' enemy and tries to push her to the edge. Satoshi Chii's scheme has also caused Saya Toma and Juichi Ninomae to forget that they are brother and sister. The siblings are headed to a life-staking fight. A girl named Maho Ueno becomes involved in their fight. To protect Maho Ueno, Saya Toma uses "spec".

Fifteen years ago, three childhood friends, Geki, Sherry and Okuma, were star-gazing and became inspired to go into space. As adults, Geki and Okuma join a mission to Mars, but their space shuttle goes missing before they could reach their destination. A year later, a monster attacks and a mysterious silver-colored warrior appears.