An urgent phone call pulls a Yale Law student back to his Ohio hometown, where he reflects on three generations of family history and his own future.

Longtime best friends Sid and Jonesie are dumped by their respective girlfriends. Both without a living situation, they decide to become "bromates", bros who are roommates, which puts their relationship to the ultimate test.

Quentin Jacobsen has spent a lifetime loving the magnificently adventurous Margo Roth Spiegelman from afar. So when she cracks open a window and climbs back into his life dressed like a ninja and summoning him for an ingenious campaign of revenge, he follows. After their all-nighter ends and a new day breaks, Quentin arrives at school to discover that Margo, always an enigma, has now become a mystery. But Quentin soon learns that there are clues, and they're for him. Urged down a disconnected path, the closer Quentin gets, the less he sees of the girl he thought he knew.

Backpacking alone on the Appalachian trail, a married woman meets a younger hiker and the two strangers become inexplicably drawn to one another.

When a psychiatrist discovers that a medication for the treatment of acne is causing teenagers to kill themselves, the pharmaceutical company sets out on a campaign to destroy the source of the threat to their billion-dollar-a-year drug.