Asuka is an aspiring model who moves to Tokyo to pursue her career. She moves into a small apartment with a friend of a friend, Kasumi. A bizarre murder occurs in the hotel across the street. The body was mutilated and repositioned into a lurid work of art. After this, a string of murders start happening all around the two girls, as if some crazed serial killer was following them. At the scene of each crime, the perpetrator leaves a black lip print, and is subsequently dubbed "The Black Kiss."

The day before summer vacation. Yoko who tastes Tallow of the third year high school student will move to Hokkaido. However, with my grandpa's selfishness, she returned from the station and decided to live at the house next to Tallow! To the feeling that should have been sorted out, the fire is put on again.

A Japanese Company funded by the USA experimenting with anti-bacteriological weapons creates a mutated humanoid rat creature which becomes violent and murders the lab technicians. The lab is condemned and its horrifying experiments kept a secret. However the strange bacteria leak from the lab and spreads to the nearby inhabitants causing a humanoid epidemic! Three people are sent to the lab to uncover the US government conspiracy that unleashed a bloodthirsty monster beyond their wildest imagination.