Wanted criminal "Helios" and his assistant stole a quantity of uranium and plan to produce weapons of mass destruction. They are planning to trade with a terrorist organization in Hong Kong. Chief Inspector Lee Yinming and Inspector Fan Kaming lead the Counter Terrorism Response Unit of the Hong Kong Police Force. Along with a Chinese senior official, a physics professor, and two South Korean weapon experts, they hope to defuse a crisis sufficient to destroy the world.

Two brothers were separated in childhood at an orphanage, only to find each other as adults 30 years later. But right after their reunion, their birth mother, who suffers from Alzheimer's disease, suddenly disappears. So Sang-yeon and Ha-yeon team up together and go on a road trip to search for her.