Angelo dreams of creating a medicine that could cure his father’s illness. With some knowledge about medicinal herbs, he makes a living as a faith healer. Everyone believes him, except Cielo Delos Santos, a doctor who swears to do everything to uncover Angelo’s secret. Things get a little complicated when Angelito, an exiled angel comes down to earth to help Angelo become a better man. As the three of them try to achieve their own goals, they realize that they need each other more than they are willing to admit.

Quadruplets are split into pairs and raised apart by their parents. They meet as adults by accident and have a tough choice to make when one needs a liver transplant.

Medy, a make-up artist, was given the chance of a lifetime to accompany a concert star to the United States for a performance. She promised her family that she will return after a week.

A few months after Ina left the position as the President of the Philippines, she is back in the media limelight as she releases a book of her life in her journey as a mother to her children and as a mother to the people of the Philippines. Ina now lives a simple life with her beloved children, together with her long-time best friend, Rowena.

Enteng wants to retire as the hero of Engkantasya and have a normal life with his family without the magical elements. Ina longs to have the right partner to be with her for the rest of her life. One day, Enteng is placed under a powerful evil spell by the evil witch Satana to fall in love with another woman. And when he meets Ina, he exerts all the effort Ina to fall for him. Ina, on the other hand, slowly opens her heart for this new opportunity of love. Enteng then tries his best to be a father to Ina’s children even if they are not fully supportive of him. But when their relationship gets serious, Ina discovers the truth – Enteng already has a family.

Bernardo hires his half-sister Bernadette as an assistant and she has no idea who he really is. Bernardo plans to make her life hell until a rival tries to lure Bernadette away and he has to fight to keep her.

Melinda Uy is a half-Filipino, half-Chinese struggling mother to four children married to a full-Chinese blood man. Her family was believed to bring curse to Olive's famiily. Because of this, Melinda was not accepted by Uy's family as one of their members. Melinda's struggling as a mother begand when she has nothing else to do but to strive and work more.

Jane, a die-hard fan, wants to win tickets to Billy Fernandez's concert. To do this she must answer the question, "What would you do if it was the end of the world?" In search for this answer she meets different people with different love stories: a 40-year old virgin named Virgie who meets a gigolo named Charles; a hopeless romantic secretary, Barbara who is helping her boss, Ken with "personal issues"; Belle who is in love with her gay best-friend, Butch, an active-executive; Verna who falls in love with a waiter named Elvis in Vietnam; Jomar who is trying to court Ayie with the help of a 35 year old mentally-challenged man named Pipoy; Patty who traces her first love, Alvin to become a model for her company.

Jane, a die-hard fan, wants to win tickets to Billy Fernandez's concert. To do this she must answer the question, "What would you do if it was the end of the world?" In search for this answer she meets different people with different love stories: a 40-year old virgin named Virgie who meets a gigolo named Charles; a hopeless romantic secretary, Barbara who is helping her boss, Ken with "personal issues"; Belle who is in love with her gay best-friend, Butch, an active-executive; Verna who falls in love with a waiter named Elvis in Vietnam; Jomar who is trying to court Ayie with the help of a 35 year old mentally-challenged man named Pipoy; Patty who traces her first love, Alvin to become a model for her company.

A mysterious and powerful being in the river catches the attention of the people living around it.