Best Friends Forever (BFF) is the 16th year anniversary presentation of Star Cinema starring the Megastar Sharon Cuneta and the Comedy Queen Ai Ai delas Alas. Sharon and Ai Ai will be playing as best friends in this comedy film helmed by box-office director Wenn Deramas of Tanging Ina and Ang Tanging Ina N’yong Lahat.

Elizabeth Pedroza is a UST Architecture graduate infatuated with her long-time school crush, John Eduque. Her world comes crushing down when she learns about the death of Eduque. She immediately goes to the wake and gets the shock of her life. She sees an older man, instead of a young man, lying in the coffin. The wife of the deceased John Eduque Sr gets piqued with her visit. A family friend’s simple question ‘who’s that girl?’ soon escalates into a grand-scale inquisition complete with kidnapping and high-profile rescue.

Four women named Res, Gay, Dolly, and Brite who swore to be friends forever, become domestic helpers when they go over to another country. However, Res is beaten to death by her employers, making the other three worry because her husband gave her one condition if she comes with her friends: that she comes home safe, sound and alive. Brite, Gay, and Dolly decide to bring their dead friend Res home.

Christine frantically flies back in the Philippines to gather evidences that will convince his Australian father not to marry Georgia her estranged mother, who she thinks has abandoned them. She takes with her Ninonu, her nanny for 20 years. Georgia, clueless of her daughter’s dark plans prepares the whole town with all excitement. Meanwhile, Christine cannot believe that Georgia is a successful Patis manufacturer in her town and is well-loved by her neighbors

Peter Kasimsiman was once a submissive son to his parents. But losing his mother at a tender age, left him with an abusive father who only knew of tending to his carriage horse, Brown Beauty. Peter is eager to win the love and attention of his indifferent Tatay. But an unfortunate incident forces him to run away from home. His horrible life starts to change its course when he meets the nurturing haciendera Helena who provides him shelter and unconditional affection he knew his father would never be able to give. Helena teaches Peter love and kindness, grooming him as the sole heir to the hacienda in the event of her death. Albeit fueled with the guidance of the good-natured foster mother, who's known for her passionate concern for her employees, Peter has an intolerable bad temper especially towards her mother's loyal servant, Maita and the latter's beautiful and gifted daughter, Samantha.

Rica has been very protective of her sister Cecil even giving up her one true love Bong JC de Vera for her sisters future and after a freak accident 8 years ago at their little Party store for Fireworks, but as they grow up under the care of their grandmother Gina Pareño their parents comeback Tonton Gutierrez and Cherry Pie Picache as they comeback and they are all grown up Rica has a fear that she's losing Cecil's love as a sister and who raised her like a parent, and even falling in love for Edzel Luis Manzano will the sisters grow apart after having people come into their lives?

A few months after Ina left the position as the President of the Philippines, she is back in the media limelight as she releases a book of her life in her journey as a mother to her children and as a mother to the people of the Philippines. Ina now lives a simple life with her beloved children, together with her long-time best friend, Rowena.

Since birth, Brando despised his gay twin brother, Brandy, who has been his burden (including the fact that he was mistaken). However, when Brandy was caught in an accident and put into a coma, Brando is forced to impersonate his twin to keep a major business from falling through. Though they had a misunderstanding, Brando gains a new appreciation as he lives his brother's life.

A man tries to keep his partner from straying by romancing the object of the man's affections himself.

Bernardo hires his half-sister Bernadette as an assistant and she has no idea who he really is. Bernardo plans to make her life hell until a rival tries to lure Bernadette away and he has to fight to keep her.