The film charts the fortunes of two women who loved each other as sisters, but whose paths diverge when the Revolution brings an end to their old way of life in the brothel.

In the spring of 1961, the Shanghai Institute of Biology, Chinese Academy of Sciences spread a news that shocked the biological world: the world's first toad without a grandfather was born, and the artificial parthenogenesis experiment was successful! Just when everyone was immersed in a festive atmosphere, an astonishing bad news made people fall into extreme grief. Because the creator of this scientific miracle and the famous biologist Dr. Jin Yuxi, he was killed by cancer without even having a look at the results of his labor.