Jake Blues, just released from prison, puts his old band back together to save the Catholic home where he and his brother Elwood were raised.

A quiet suburb in Southern California is terrorized by a mysterious murderous monster living in a cave. As the bodies pile up -- with incriminating banana peels always near by the crime scene -- a group of teens stumble on the guilty party: a 20-million-year-old Schlockthropus, an ape-like creature with a sense of the absurd.

The daughter of a star quarterback is falsely accused of drug smuggling while visiting a small Caribbean island. After his attempts to get her out of jail fail, his coach and teammates show up in full football gear and armed to the teeth, ready to free her by any means necessary.

Finally released from prison, Elwood Blues is once again enlisted by Sister Mary Stigmata in her latest crusade to raise funds for a children's hospital. Hitting the road to re-unite the band and win the big prize at the New Orleans Battle of the Bands, Elwood is pursued cross-country by the cops.