Monroe Salisbury plays a man of the Northwoods. This time he's Silent Duval, of mixed-blood origin, who distinguishes himself as a football player at Stanford University. But his Indian blood makes him an outcast and when he is injured, only one white girl is there to comfort him. So he decides to return home where he'll get some respect.

Mary Doone (Theda Bara) is a poor British girl who runs away from her adopted family because the father made a pass at her. She lives at a parish house, and at the outbreak of World War I, she becomes a Red Cross nurse.

Vere Herbert lives with her wicked mother, Lady Dolly (Marie Curtis), who is living in sin with Lord Jura (Glen White). Although Vere is in love with an opera singer, Lucien Correze (Harry Hilliard), Lady Dolly convinces her that marrying the dissolute Prince Zouroff (Walter Law) will save her father's honor. But the Prince makes her miserable and insists on having his mistress, Jeanne deSonnaz (Caille Torrez), live with them.

Desperate to change her vixenish image, Theda Bara was called upon to play a sweet young thing (she was nearly 30) who sacrifices herself for the happiness of her sister (Claire Whitney).

Camille is a courtesan in Paris. She falls deeply in love with a young man of promise, Armand Duval. When Armand's father begs her not to ruin his hopes of a career and position by marrying Armand, she acquiesces and leaves her lover. However, when poverty and terminal illness overwhelm her, Camille discovers that Armand has not lost his love for her.

Mary Lynde (Theda Bara) is an innocent girl who has grown up in New York's Greenwich Village. One of the artists there, Felix Benavente (Sidney Mason), uses her as model when he paints a portrait of the Madonna for a church. His friend Robert Sinclair (Hugh Thompson) corrupts Mary so that her father (Walter Law) casts her from his home. She goes to live with Sinclair in his mountain lodge, but after the birth of a child, he callously casts her aside. Subsequently, her baby dies and she sinks to the depths of despair.

A royal princess gives her time to the Red Cross, and works alongside a young American doctor.

Margaret Jarnette discovers that her husband Victor has been cheating on her and confronts him. Outraged, Victor has his lawyer rewrite his will so that in the event of his death, his brother Richard will get custody of his daughter Muriel, and his wife won't. When Victor dies shortly afterward, Richard suspects that Margaret had murdered him and takes custody of Muriel. However, he soon begins to suspect that things may not be quite as cut-and-dried as he thought they were.

Bertha Holt, a stenographer, is alone in New York. She becomes acquainted with John Rawls, who tricks her into going to a hotel with him telling her he will get a minister to marry them. Bertha, who believes in Rawls, agrees. Rawls returns without the minister and Bertha guesses his real purpose.

Western sheriff Bob Wells is preparing to marry Sally Morgan; she loves part-Indian Wanenis, whose race is an obstacle. Sally flees the wedding with hypochondriac Henry Williams, who thinks he's just giving her a ride; but she left a note saying they've eloped! Chasing them are jilted Bob, Henry's nurse Mary (who's been trying to seduce him) and others.