Spain, 1755. Ana is sent to a cloistered monastery where several nuns are afflicted by a mysterious disease. With the help of an unorthodox priest, the young novice uncovers an ancient legend and malevolent force: a bloodthirsty upiro.

Carla receives a disturbing call from her mother, Anne. Her grandmother, Mamie, wants to die. With this news, they decide to travel to be together one last time and say goodbye to Mamie. The reunion, initially affectionate, becomes muddied as old grudges buried under a history of family abandonment come to light.