A musical that brings a bit of the history of Brenda Lee, called the "guardian angel of transsexuals", activist who founded the first support house for people with HIV/AIDS in Brazil. She has a pension for trans women who, for the most part, live off prostitution. Despite the reality of violence in which they live, inside the house, the transsexuals are welcomed by Brenda, who teaches them to want more out of life.

Picumã is an action film that follows the journey of three travestis. One of them, Cleo, mysteriously disappears. Lua and Shaiene set out on a search to uncover their friend’s whereabouts. Time is running out, and their success will determine whether Cleo lives or dies.