Four years after their crazy night of escapades, Manuel, Efrain, and El Gordo's friendship has survived well into their college years. Now, living together they decide to throw an end of summer party to rival all parties. What they don't know is that Bibiana, an escort from Manuel's past comes back to stir things up, forcing them to make decisions that they may not be prepared to make.

In a party, Fico bumps into Manolo, an old friend from school, a rascal who is running away from the mob who is after him. To take shelter in his friend house, Manolo fakes a desease that will start a series of entanglements that will change their lives. Soon they will find out that everything but friendship is an illusion.