Nikolaus Kaminsky is a former police profiler who has been living in seclusion for 20 years, with no contact with the outside world. Only his neighbor's daughter Simone manages to coax him out of his shell from time to time. When he threatens the 12-year-old with a knife for no apparent reason one day, detectives Jäger, Kraft, and Hoffmann are called in. The police are actually busy with a kidnapping case, but when Kaminsky casually leads the investigators to the solution of the case, a long-forgotten case of child murders suddenly becomes relevant again. The last victim of the serial killer, who remains unknown to this day, was Kaminsky's daughter. When Kaminsky then warns the police about a new kidnapping case, the suspicion arises that the killer, believed to be dead, is back at work.

Shortly after being released from prison, an ex-convict is abducted by a masked stranger. This is a case for Inspector Jäger, who, due to a lack of work in the Calw homicide division, has to assist colleagues in other departments.

This time, Tatort Calw takes us to the stage, the world's greatest stage. During an amateur theater performance, a version of Romeo & Juliet "translated" into Swabian, a shot is fired according to the script. But the bullet was not a blank. The result: undertaker and amateur actor Günther Jourdan lies dead on the stage. A new case for Calw detectives Jäger, Kraft, and Hoffmann, who now find themselves confronted with a multitude of quarrels, motives, and suspects within the theater troupe. Secret affairs, property disputes, pregnancies, and personal animosities. The theater people are like a prime-time soap opera on private television. However, when the alleged perpetrator is identified, there is a surprising twist.

Through an inheritance, a group of friends find out that their grandfathers had found crates of gold in the wreckage of a crashed plane in the final days of the Second World War. A short time later, the men were killed and the gold was never found. Now the gawky grandsons are trying to recover the treasure. In the process, they come up against crooks, speculators and old and neo-Nazis.

A babysitter is brutally murdered. The Calw trio of investigators Jäger, Kraft, and Hoffmann soon make a shocking discovery: an apparently psychopathic killer is imitating famous movie murders. And the list of role models is long... At the same time, blind Alex meets shy painter Daniel, who soon comes under suspicion. But is the shy artist really a brutal murderer? The investigation ultimately leads the detectives into the world of the German Armed Forces and culminates in a spectacular showdown involving a tank on a rampage.

Because detectives Jäger and Kraft botched an unauthorized operation, they now have to face the consequences: they are demoted and placed under the command of their colleague Hoffmann. In their private lives, too, things are not as they should be. While Jäger is kept busy at night by his young children, Lola and Andreas' relationship is in crisis. The Calw investigators are really not having an easy time of it at the moment. And then there's their new case, which seems to be a tough one. When businessman Till Ritter is found dead, everything seems clear at first: suicide. But the matter becomes more complicated. Why was Ritter's daughter kidnapped? And what is his son Philip hiding? And what does the body found in a nearby lake have to do with it? The three detectives and their new colleague still have a lot of work ahead of them, because there is still a long way to go before all the questions are answered and the case can be closed...