Former detective Brenner has become an ambulance driver and finds himself, much to his dismay, caught up in a war between two rival first aid organizations.

Ever since Rappelkopf was once deceived by a con man, he has become the epitome of a suspicious, stubborn misanthrope and a family nuisance. His wife and daughter, as well as his servants, suffer from his bad moods, accusations, and insinuations. The kind, alpine mountain spirit Astragalus, the King of the Alps, wants to rescue the grumpy man from his constant discontent and misanthropy. He promises to remedy his situation and makes Rappelkopf an offer he cannot refuse: he is to become his alter ego, to slip into another, better form. In the guise of his brother-in-law, the tyrant is to visit his family to convince himself of their loyalty and love. The King of the Alps, in turn, wants to appear as Rappelkopf, the living mirror of the true family despot, in order to morally purify him through self-knowledge.

Stingo, a young writer, moves to Brooklyn in 1947 to begin work on his first novel. As he becomes friendly with Sophie and her lover Nathan, he learns that she is a Holocaust survivor. Flashbacks reveal her harrowing story, from pre-war prosperity to Auschwitz. In the present, Sophie and Nathan's relationship increasingly unravels as Stingo grows closer to Sophie and Nathan's fragile mental state becomes ever more apparent.