Di sebuah pesantren di Kediri, ada seorang pemuda bernama Syamsul (Dude Herlino) yang rela meninggalkan kehidupannya yang cukup nyaman demi tekadnya untuk belajar menuntut ilmu dan bergabung dalam pesantren.Kehidupan dalam pesantren membuatnya dekat Zizi (Meyda Sefira), seorang putri pemilik pesantren yang sebelumnya pernah menolong Syamsul saat dia dijambret di kereta.

Lisa is brutally raped by Hengky and his two friends, Hengky and Baron, and is left on the streets. Due to the trauma, Lisa develops mental illness. She is treated by Dr. Iwan, a psychiatrist, while her case is handled by police captain, Markus, Iwan’s friend. The case is difficult to solve as Lisa has amnesia and cannot remember her past. After the treatment at the hospital is completed, Lisa is invited to stay at Dr. Iwan’s house, as he wants to study her further for his doctoral thesis. Through both friends’ diligence, they are able to find Lisa’s mother and siblings. As a result, Lisa’s memory begins to recover.

Tragically widowed on her wedding night, Anggun attempts to rebuild her life by returning to university, where she finds solace in her growing romance with Indra, a fellow student who works as a driver to fund his education. However, their relationship is threatened by a scandal when Indra's employer, the wealthy and manipulative Wieke, becomes pregnant and coerces him into taking the blame to cover up the identity of the real father. Caught in a tangled web of gossip and duty, Anggun finds her new chance at happiness jeopardized by a lie she cannot disprove.

In Jakarta, a young journalist struggling to escape from the confines of familiar obligations, receives a telegram informing him that his mother is dying.