Strange things begin to occur as a tiny California coastal town prepares to commemorate its centenary. Inanimate objects spring eerily to life; Rev. Malone stumbles upon a dark secret about the town's founding; radio announcer Stevie witnesses a mystical fire; and hitchhiker Elizabeth discovers the mutilated corpse of a fisherman. Then a mysterious iridescent fog descends upon the village, and more people start to die.

Carter Frazier looks to salvage his foundering life by finding a famous lost work of art that's gone missing in far away Marfa, Texas.

Andy LeBeau is a fallen angel of sorts. He keeps messing up and causing trouble in angel training. The archangel, Michael, decides to give him one more shot. His mission: Help out the problems of three cases. First, the Desautel family, who are on the edge of breaking up. Then, the McNulty family, who are workaholics. Finally, Dorothea Powell who is a secluded, grumpy old woman. Andy's guide on earth is Blake, who is none too thrilled to work with Andy.

After failing to kill stubborn survivor Laurie and taking a bullet or six from former psychiatrist Dr. Sam Loomis, Michael Myers has followed Laurie to the Haddonfield Memorial Hospital, where she's been admitted for Myers' attempt on her life. The institution proves to be particularly suited to serial killers, however, as Myers cuts, stabs and slashes his way through hospital staff to reach his favorite victim.