Set 15 years after "Twentieth Century Boys," Kanna (Airi Taira) reunites with several main characters from the first film in an attempt to stop Friend's increasing influence over the world and continued plans to eliminate humanity, as detailed in the New Book of Prophecy.

In 1969, Kenji, an elementary school kid and his friends built a secret base during their summer holidays. They fantasized that they had to fight villains who were out to conquer the world and wrote them in the Book of Prophecies. Years later in 1997, Kenji becomes a convenience store manager and leads a regular life after giving up his dreams to become a rock star. His boring life is suddenly turned upside down when his old classmate dies mysteriously and an entire family in the neighbourhood disappears. At the same time, a religious cult and its mysterious leader, Friend emerges and a strange chain of events duplicating exactly the events described in the Book of Prophecies follow. Is this the beginning of the end of the world? Who is Friend?

A hustler who gets in trouble with a gang boss in the port town of Sukago agrees to make good with the don by putting him in contact with a mysterious hitman — an assassin the hustler has no idea how to contact. Instead, he hires an actor to play the role, though the thespian has no idea what he's getting into.

The final showdown, and the final reveal. Who is Friend? How can he be stopped?

In 1944, the American military lands on the shores of Saipan. Refusing to commit suicide with his superiors or be forced into camps for prisoners of war, Captain Oba Sakae leads a group of his men and other similarly minded local residents into the mountains. Even after hearing reports of the Japanese military's surrender, Oba dismisses the reports as propaganda and continues to launch guerilla attacks against the American soldiers, earning him the nickname "The Fox". Soon, even the American commander who's charged with the task of capturing Oba comes to admire his persistent enemy.

A love story written by an ordinary housewife is going to be broadcast as a radio drama and almost everyone among the crew insists on changing various parts of the play to their liking.

Two newlyweds decide to build their dream home, and hire an old friend named Yanagisawa to design it. Unfortunately, Yanagisawa isn’t licensed to build homes, so they call in the wife’s father, a retired carpenter, to help out. When Yanagisawa’s contemporary ideas clash with the old carpenter’s traditional Japanese methods, the project becomes a huge mess.

Having put down his sword and given up the will to fight, the masterless samurai Iemon lives in solitude while being haunted by his violent enigmatic past...

Veteran suit actor Wataru Honjo, a 48-year-old Bruce Lee fan who has spent 25 years in the business, clashes with rookie Ryo Ichinose until fate brings them together—leading Wataru to a once-in-a-lifetime chance to take on a dangerous Hollywood action role.