A group of college students discovers that an urban legend is not a myth and release a deadly spirit, housed in an intelligent bird whose mission is to seek revenge on the descendants of their ruthless and heartless ancestors.

After college roommates Kyle and Jakob both get bit by radioactive spiders, they find themselves with amazing powers. But when Jakob's insecurities clash with Kyle's easy-going attitude, can the two Spider-Bros be the heroes Kutztown University needs? Does it even need them?