The mobster husbands of three 1978 Hell's Kitchen housewives are sent to prison by the FBI. Left with little but a sharp ax to grind, the ladies take the Irish mafia's matters into their own hands — proving unexpectedly adept at everything from running the rackets to taking out the competition… literally.

Photographer Barnard Jacobs is dying and Ashley, the woman he loves, won't admit her feelings for him. She's too wrapped up in her cocaine addiction and desire to find a wealthy husband. When fashionista Madeleine begs Barnard to call Ashley for drugs, a party develops. Madeline pairs off with a rich tech executive named Boccaccio. Barnard goes home, where Ashley, seeking peace and solitude, joins him. In flashback, Barnard recalls how his best friend Pickering hired him to take photos of women's eyes. He hired Ashley and the two forged a deep connection. Back in the present, Boccaccio and Madeleine do drugs and become removed from the world. As Barnard learns death is near, he reaches out to Ashley in a final attempt to save both of them.