Ex-con turned private investigator Bradford Galt suspects someone is following him and maybe even trying to kill him. With the assistance of his spunky secretary, Kathleen Stewart, he dives deep into a mystery in search of answers.

In 1932, a cop is killed and Frank Wiecek sentenced to life. Eleven years later, a newspaper ad by Frank's mother leads Chicago reporter P.J. O'Neal to look into the case. For some time, O'Neal continues to believe Frank guilty. But when he starts to change his mind, he meets increased resistance from authorities unwilling to be proved wrong.

In 1867, a gang robs a bank and flees into the desert. Out of water, the outlaws encounter a ghost town called Yellow Sky and its only residents, a hostile young woman and her grandfather.

A medical examiner discovers that an innocent shooting victim in a robbery died of bubonic plague. With only 48 hours to find the killer, who is now a ticking time bomb threatening the entire city, a grisly manhunt through the seamy underworld of the New Orleans Waterfront is underway.