Tony Jaa is the leader of the Panter Squad - a group of martial arts madmen employed by a notorious General and Cartel kingpin on the border of Thailand and The Golden Triangle. They have kidnapped a noted Explorer who has been searching for an ancient priceless artefact that the General is desperate to find and profit from. A team of ruthless mercenaries leads a crack team to free the Explorer, crush the General and deadly Panther squad. But before doing so they must overcome the fearsome Black Goblins and the crazed Kung Fu Zombies.

Panna and Tony play members of a desperate gang of thieves who are forced into hiding after a robbery goes wrong; when the police launch a raid on their hide-out, the pair are forced to make a bid for freedom, and in the ensuing battle, Panna's 'brother' is shot and killed. Narrowly escaping the clutches of the law themselves, the duo plan to take revenge on Pitak, the cop who fired the fatal bullet.