Vignettes weaving together the stories of six individuals in the old West at the end of the Civil War. Following the tales of a sharp-shooting songster, a wannabe bank robber, two weary traveling performers, a lone gold prospector, a woman traveling the West to an uncertain future, and a motley crew of strangers undertaking a carriage ride.

New Mexico Territory, 1880. Rio Cutler and his older sister Sara must abandon their home after an unfortunate event happens. In their desperate flee to Santa Fe, they cross paths with the infamous outlaw Billy the Kid and his gang, who are ruthlessly pursued by a posse led by Sheriff Pat Garret.

In the summer of 1859, a widowed physician reluctantly agrees to take a recently freed slave and her mysterious Caucasian daughter on a five-day journey through the bloody West to find a distant town's Faith Healer. The woman believes her daughter is possessed. The doctor believes she simply carries The Sickness. Either way the fact remains that every living thing the girl touches mysteriously dies.