A ring of call girls leaves the "business" when one of them is murdered. The survivors change their names and leave town. However, they are reunited 15 years later when another one of them is murdered and the rest realize that they are all being tracked by the same serial killer.

Young actor Miles Hottonian attempts to become the hard-living leader of the Beat Generation, Jack Kerouac. After finding an online casting call for a Miloš Forman project about the great writer, Miles enlists the help of the last NYC checker cabbie Charlie Grebbini to drive him from New York to Los Angeles to experience life on the road in time for the audition, an adventure that will ultimately change their lives forever.