Twenty-eight weeks after the spread of a deadly rage virus, the inhabitants of the British Isles have lost their battle against the onslaught, as the virus has killed everyone there. Six months later, a group of Americans dare to set foot on the Isles, convinced the danger has passed. But it soon becomes all too clear that the scourge continues to live, waiting to pounce on its next victims.

The abolition of slavery in the British Caribbean in 1834 prompts Gillanders, Arbuthnot & Company in Calcutta, a part of the East India Company, to recruit Coolies from India to fill the resulting labor void. The company hires Sinha, a fierce small-timer to sell dreams of El Dorado to the unsuspecting, impoverished Coolies who are signed to five-year contracts as indentured servants. Upon the Coolies' arrival in British Guiana in 1838, the British planters promptly enslave them to ensure that the growth of sugar in the British West Indies will continue uninterrupted. John Scoble of the British and Foreign Anti Slavery Society arrives on the colony a year later to discover a new form of slavery; this time on the backs of Indians.

Due to climate change a new race of flesh eating predators arise, who invade and eat everything living on earth. In a residential neighbourhood in a Danish suburb nightmare like scenes are being experienced first hand through the eyes of two teenage brothers, who can't stand each other, but are now suddenly forced to barricade themselves in the basement together, to avoid getting eaten. From one day to another, without parents and without electricity, food, water and contact to other people, the brothers have to learn to live together in their vital protection bunker, while monsters move past the basement windows and heavy, sharp claws can be heard moving around upstairs on the wooden floors.