A "barkada" of five–Kurt, Ma-an, Denzel, Hadji, and Junamae experiences the various faces of adulting in a world that seems to be losing faith in the concept of love.

Ikay, a girl stricken with the skin disorder vitiligo, is often described as a living meme within her university. Upon discovering the powers of a magical black lipstick, "Icky Ikay" leads a double life as a social media influencer named Jessie. Set in a world of vlogs, dating apps and live videos, Black Lipstick reimagines the concept of beauty and acceptance in the age of social media.