Set in the Sidist Kilo campus of Addis Ababa University, Kezkaza Welafen directly addresses the social tensions of everyday life for Ethiopian university students with the dangers of HIV/AIDS as its central theme. It follows the story of the female protagonist Selam, a promising university student and advocate for the prevention of HIV/AIDS who secretly believes she too is living with the disease.

a man has to complete his mission of helping homeless orphans, and faces obstacles throughout his day