In this sequel to the Off-Broadway musical hit, the Little Sisters of Hoboken put together another musical revue, to thank all the people who saw the first show and helped them solve their little "monetary" problem.

An unfortunate convent cooking accident causes most of the order of the Little Sisters of Hoboken to die of botulism. Before all of the deceased sisters can be buried, Reverend Mother Superior (Rue McClanahan) buys a camcorder and VCR for the convent - resulting in not having enough money to bury the four remaining sisters (which, by the way, are temporarily being stored in the freezer). In order to raise money to bury the four dead sisters, the Little Sisters of Hoboken (well, what's left of them) put on a riotous revue packed with hilarious, show-stopping song and dance numbers.

After breaking up with her girlfriend, a nightclub singer, Jane, answers a personal ad from Robin, a real estate agent with AIDS, seeking a cross-country travel partner. On their journey from New York City to Los Angeles, the two stop by Pittsburgh to pick up Jane's friend Holly, who is trying to escape an abusive relationship. With three distinct personalities, the women must overcome their differences to help one another.