Patrick, 20-years-old, lives in Paris with his older boyfriend. He runs a teenage pornography website, which results in a prison sentence following a raid at a party. Mário, 8-years-old, was kidnapped 12 years ago in Portugal. Patrick and Mário are the same person with two conflicting identities: a life in Paris filled with parties, drugs, and promiscuity and a new rural life in Portugal, where he feels obliged to reconnect with a broken family.

In 2011 Portugal began the so-called "year of the Troika" (EU, IMF and ECB budget cuts and economic restructuring), with the level of debt among the Portuguese people reaching staggering amounts and a growing number of families and companies unable to repay their installment loans. Jorge is an unemployed boxer on the verge of losing his son and his wife, who has decided to return to Brazil. As a means of paying off his debt and persuading his wife to remain in Portugal, Jorge accepts a job with a debt-collection agency, which will drag him into a world of violence and crime.

Inspired by the work of Bertolt Brecht and filmed in Porto's former industrial slaughterhouse, A Santa Joana dos Matadouros is a meta-cinematic essay about the labor market in times of economic crisis in Europe. The film explores the possibilities of cinema in its relationship with theater and brings together a cast of professional actors, amateurs, renowned artists from various disciplines, and a group of unemployed residents of Vale de Campanhã.