Hobbs has Dominic and Brian reassemble their crew to take down a team of mercenaries; Dominic unexpectedly gets sidetracked with facing his presumed deceased girlfriend, Letty.

Morioh, 1999—a normally quiet and peaceful town has recently become a hotbed of strange activity. Jōtarō Kūjō, now a marine biologist, heads to the mysterious town to meet Jōsuke Higashikata. While the two may seem like strangers at first, Jōsuke is actually the illegitimate child of Jōtarō's grandfather, Joseph Joestar. When they meet, Jōtarō realizes that he may have more in common with Jōsuke than just a blood relation. Along with the mild-mannered Kōichi Hirose and the boisterous Okuyasu Nijimura, the group dedicates themselves to investigating recent disappearances and other suspicious occurrences within Morioh. Aided by the power of Stands, the four men will encounter danger at every street corner, as it is up to them to unravel the town's secrets, before another occurs.

In an American desert town circa 1955, the itinerary of a Junior Stargazer/Space Cadet convention is spectacularly disrupted by world-changing events.