Emily Johnson, her boyfriend Bobby and their friends Clare and Jude are recent college grads driving cross-country, taking a last vacation together before they face the "real" world. An accident leaves them hurt and stranded on a lonely Louisiana road. When the ambulance arrives, it whisks them to Mercy Hospital.

Angela is throwing a decadent Halloween party at New Orleans' infamous Broussard Mansion. But after the police break up the festivities, Maddie and a few friends stay behind. Trapped inside the locked mansion gates, the remaining guests uncover a horrifying secret and soon fall victim to seven vicious, blood-thirsty demons.

As an ex-gambler teaches a hot-shot college kid some things about playing cards, he finds himself pulled into the world series of poker, where his protégé is his toughest competition.