The UN General Assembly regards antibiotic-resistance as a "global and most urgent threat". The WHO alarms that we could fall back into a "post-antibiotic age". The film tells us how we got there: It is a story about how negligence, greed, and short-sightedness have rendered the lifesaving effects of antibiotics powerless. It is a science-thriller about disillusioned, fighting doctors, rebellious scientists, patients wrestling with life-threatening diseases and diplomats searching for a global solution. They all are Resistance Fighters.

The story of Sukhadi, a twelve-year-old Adivasi girl who makes a daily trip to a sleepy railway station to fetch water. This banal activity is transformed into an adventure by her chance meeting with Zainaab, a beautiful and mysterious, thirteen-year-old gypsy girl. Zainaab challenges Sukhadi to jump on to the old-fashioned narrow gauge train that takes holiday makers to Matheran on top of the mountain.