Mirko and Manolo are best friends and live in the suburbs of Rome. They both live in poor conditions with their single parents, are still in school and struggle with occasional odd jobs to make ends meet. Together they share dreams of women, of sex and money, of a better life to come. Then, after killing a man in a hit-and-run one night, they get involved with the local mafia and their lives change dramatically.

The story is set in an indefinite time. In a dungeon, five people fight for their survival: three women, Blonde, Black and Red; a theologian and a young doctor. Out of this hiding place reigns the APOCALISSE. Evil was generated by a zero patient and a group of ex-soldiers, called "Exterminators", crucifies any person you meet to find the origin of the evil. Are the five really safe in this place or is there something they don't know?