Ethan Hunt and his team are racing against time to track down a dangerous terrorist named Hendricks, who has gained access to Russian nuclear launch codes and is planning a strike on the United States. An attempt to stop him ends in an explosion causing severe destruction to the Kremlin and the IMF to be implicated in the bombing, forcing the President to disavow them. No longer being aided by the government, Ethan and his team chase Hendricks around the globe, although they might still be too late to stop a disaster.

Famed forensic psychiatrist Dr. Jack Gramm enjoys a reputation as one of the most sought-after profilers around. His expert testimony has resulted in the conviction of many criminals, including serial killer Jon Forster. On the eve of Forster's execution, one of Gramm's students is murdered in a vicious copycat crime, and Gramm himself receives an ominous message informing him that he has less than 90 minutes to live.

After having suffered serious head trauma, Brooke tries to regain her normal life despite having lost all memory. Her wealthy fiancé helps her back to recovery in their beautiful country home. Little by little, as her memory comes back, she realizes that her fiancé is not who he says he is. The fortune is hers.