After Inspector Zenigata is reassigned from the Lupin case and grows despondent, master thief Lupin the Third decides to help him get his old job back, teaming up with the old man to destroy the international weapon smugglers Shot Shell. Together with Lupin's long-time partners in crime, they steal a nuclear Russian submarine and enlist the help of a nuclear physicist named Karen, who keeps suspiciously eyeing Lupin's partner Jigen. If that weren't enough, Zenigata's Interpol successor is an assassin who aims to pick off the Lupin gang one by one.

The infamous bandit Harimao hid a treasure, and to retrieve it, Lupin and the gang must gather three lost statues. When the Nazi-like group Neo-Himmel make a run for the goods, Lupin reluctantly partners with the aging "double-O" MI-6 agent Sir Archer and his granddaughter Diana to gather the statues first. Can this unorthodox team bond well enough to see this mission through?

A simple diamond heist leads Lupin into the machinations of a bizarre cult based around the prophecies of Nostradamus. They kidnap Julia, the daughter of Douglas, a wealthy American who is seeking the presidency, along with Lupin's diamond. At stake is the lost book of prophecy Douglas holds in the vault at the top of his skyscraper.

Fujiko and Lupin are kidnapped by Malkovich, a notorious criminal escaped from Alcatraz who forces Lupin to steal the "Bull's Eye," a precious stone.

When Lupin heads to the kingdom of Zufu to pilfer its treasure, he incurs the wrath of its psychotic ruler General Headhunter, who places a dead-or-alive bounty on his head.

High school senior Mio Segawa becomes pregnant with her boyfriend, Nagisa. Unable to confess her pregnancy to Nagisa or her family, Mio confides in her best friend, Natsumi. Despite facing various challenges, Mio decides to express the feelings she had never put into words and heads toward Nagisa. Set in the UNESCO World Heritage city of Kumano, this story delicately depicts the past and future of those living in this town, showcasing the emotional connection between a young couple.

A multitude of guests visit the same cheap Tokyo apartment at different times, unaware of the gruesome creature waiting for them.