A female CIA agent is assigned to train and lead an all-female squad to Colombia to stop a renegade agent who has hired himself out to a drug cartel.

Models all over town are ending up on the wrong side of a razor-sharp blade, and police are baffled by the surgical precision of the corpse mutilation. David, a local photographer who knew a couple of the murdered women, finds his world turn upside down as the streets run red with blood.

After a man's sister is killed by two gunmen who seemingly come out of nowhere, he manages to find and kill them. He then discovers that the men he killed were part of a multi-millionaire's bizarre "death game", where someone is hunted through the streets of Los Angeles by teams of killers who get a big-money prize for killing their quarry--and he realizes that now he is "it".