Julia Kerbridge is working hard to get her doctorate. Suddenly, she finds herself the guardian of her young niece, Amanda, after the 7-year-old witnesses her parents' murder and is rendered mute. Julia soon discovers that her dead sister and brother-in-law may have held a secret life. Now, she must risk everything as the killers are still hunting Amanda for her parents' secret.

In a Canadian metropolis, failed actor David shares a place with the bookish Candy, whom he dated before coming out as gay. While David, who now waits tables, pursues an aimless romance with a younger coworker, Candy dabbles in both same-sex and heterosexual affairs. As David and Candy's odd assortment of friends — including a telepathic sex worker and an ill-tempered yuppie — pass in and out of their beds, a serial murder stalks the city's women.

What happens when you don't remember being on vacation? Neurological medicine resident Elizabeth develops a drug and, unknowingly, ends up going from researcher to guinea pig.