Cheech & Chong are invited to a celebrity party in Amsterdam. When they get there, however, it turns out that the guy who invited them has taken off with all the money. They are actually expecting Burt Reynolds and Dolly Parton, so our heroes get to be Mr. Burt and Mr. Dolly.

A plane crashes in the Amazon jungle, and its passengers must battle their way through cannibals, slave traders, wild animals and murderous piranha fish to safety.