Five years after throwing a killer party and stealing Muffin away from alpha-male Zeta frat member Bud, head party nerd Ritchie is married (to Muffin!) and runs a detective agency.

A taxi driver gets more than he bargained for when he picks up two teen runaways. Not only does the pair possess supernatural powers, but they're also trying desperately to escape people who have made them their targets.

Wayward actor, Jerry Stax is whisked away by concerned pal, Terry Ruggles, to a remote locale in deep Americana, where an enigmatic "Doctor" runs an extraordinary clinic for creative rejuvenation. While there, Jerry navigates his way through the various stimuli of the other curious "participants" and seemingly inexplicable methods of Dr. Buck. Soon enough, outside forces threaten the sanctity of Buck's operation, as strange familial ties and unquiet minds unravel.

A young couple adopts a traumatized child, unaware that her parents are fugitives and murderers who will do anything to get her back.