40-year-old Arnold Gardner is put in charge of the talk show "The Twenty-fifth Hour" after the death of the former host Duncan Mackay. His role on screen creates immediate interest and the program becomes a great success with TV audiences. This proves to be a period of great satisfaction for Arnold, but his childhood friend, Eddie Greenberg, suddenly comes on the scene. Eddie is ill and frustrated by lack of success, and is so resentful and envious of Arnold's fame that he wants him to make a full public confession of a "sin" he committed in his young days.

U.S. Marshal Sam Gerard is accompanying a plane load of convicts from Chicago to New York. The plane crashes spectacularly, and Mark Sheridan escapes. But when Diplomatic Security Agent John Royce is assigned to help Gerard recapture Sheridan, it becomes clear that Sheridan is more than just another murderer.