Joel Barish, heartbroken that his girlfriend underwent a procedure to erase him from her memory, decides to do the same. However, as he watches his memories of her fade away, he realises that he still loves her, and may be too late to correct his mistake.

Tragedy strikes a married couple vacationing in the Moroccan desert, which jumpstarts an interlocking story involving four different families.

Young lovers Sailor and Lula hit the road to start a new life together away from the wrath of Lula’s deranged, disapproving mother, who has hired a team of hitmen to cut the lovers’ surreal honeymoon short.

One day at work, unsuccessful puppeteer Craig finds a portal into the head of actor John Malkovich. The portal soon becomes a passion for anybody who enters its mad and controlling world of overtaking another human body.

Two gangsters seek revenge on the state jail worker who during their stay at a youth prison sexually abused them. A sensational court hearing takes place to charge him for the crimes.

In honor of his birthday, San Francisco banker Nicholas Van Orton, a financial genius and a cold-hearted loner, receives an unusual present from his younger brother, Conrad: a gift certificate to play a unique kind of game. In nary a nanosecond, Nicholas finds himself consumed by a dangerous set of ever-changing rules, unable to distinguish where the charade ends and reality begins.

When a promised job for Texan Michael fails to materialize in Wyoming, Mike is mistaken by Wayne to be the hitman he hired to kill his unfaithful wife, Suzanne. Mike takes full advantage of the situation, collects the money, and runs. During his getaway, things go wrong, and soon get worse when he runs into the real hitman, Lyle.

What happens when a person decides that life is merely a state of mind? If you're Betty, a small-town waitress and soap opera fan from Fair Oaks, Kansas, you refuse to believe that you can't be with the love of your life just because he doesn't really exist. After all, life is no excuse for not living. Traumatized by a savage event, Betty enters into a fugue state that allows -- even encourages -- her to keep functioning... in a kind of alternate reality.

Mary Faith Rapple, a bright high school senior, has never been part of the "in crowd." She teaches a night class, cares for her widowed father and pretty much keeps to herself. When a fellow loner moves to Due East, she finds herself in a relationship for the first time, leading to a small town scandal that changes her life forever.

Buddy Amaral, a successful and self-absorbed Los Angeles advertising executive, switches airline tickets with a stranger just before boarding a long-delayed flight so that he might enjoy an overnight fling with a pretty Dallas businesswoman. When the plane goes down, killing all aboard, Buddy's guilt soon turns into an alcohol problem. As part of his 12-step program, Buddy seeks atonement and decides to seek out the woman he thinks he's left a widow.