The discovery of a massive river of ectoplasm and a resurgence of spectral activity allows the staff of Ghostbusters to revive the business.

After returning home from the Vietnam War, veteran Jacob Singer struggles to maintain his sanity. Plagued by hallucinations and flashbacks, Singer rapidly falls apart as the world and people around him morph and twist into disturbing images. His girlfriend, Jezzie, and ex-wife, Sarah, try to help, but to little avail. Even Singer's chiropractor friend, Louis, fails to reach him as he descends into madness.

A local New York City mobster named Tony Thick is expecting $5 million in cash to be delivered by Lenny Long from Los Angeles. Soon enough he realizes Lenny is missing, and it's unknown whether he is dead or he stole the money and ran away. Thick sends Shady, his made man, to L.A. to look for the missing cash. In his search, Shady meets Lenny's baby-desperate wife Sally, his ditsy mistress Eve, his muscle headed brother Louis, his quirky neurosurgeon Dr. Hooker, and a crew of other nut jobs. None of them know where Lenny is or what happened to him, but they all know that Lenny promised them a share of the money. With Lenny discovered in the San Fernandino hospital, drifting in and out of a coma, Shady has to discover where the money is.

Spike Fumo is an Italian kid apsiring to be a boxer. He falls in love with a rich girl, who turns out to be the daughter of a Mafia boss. Spike is threatened to leave Bensonhurst by the mob, and then goes to a poverty-stricken Puerto Rican part of Brooklyn.