Based on one of the most critically acclaimed comics of all time. A mysterious plague has wiped out all men on the planet, and women are left to pick up the pieces of society. The only surviving man is Yorick, an amateur escape artist who is the key to the continual survival of the human race. Special Agent 355 is tasked to protect his life at all costs. Luckily, she's really good at her job.

When a clumsy deadbeat accidentally kills his landlord, he must do everything in his power to hide the body, only to find that the distractions of lust, the death of his beloved brother, and a crew of misfit characters force him on a journey where a fortune awaits him.

On a steamy New Orleans afternoon, Sam Deuprey decides to surprise his beautiful wife, Ashley, for their anniversary and comes home early. But Ashley is not alone in the bedroom. She and her lover, Damien are about to learn how far a jealous husband will go.

A young woman studying the habits of webcam chat users from the apparent safety of her apartment witnesses a brutal murder online and is quickly immersed in a nightmare in which she and her loved ones are targeted for the same grisly fate as the first victim.