Under a powerful Mayan curse, snakes are hatched inside a young woman, slowly devouring her from within. Her only chance for survival is a powerful shaman who lives across the border. With only hours to live, she jumps on a train headed for Los Angeles. Unfortunately for the passengers aboard, they are now trapped, soon to be victims of these flesh-eating vipers.

A maximum-security prison goes into serious lockdown mode when a shape-shifting demon with an insatiable taste for human flesh unleashes its fury on the inmates and guards.

Based on a true story, "House On The Hill" is a true crime melodrama with strong horror elements, chronicling the outrageous 1980s murder spree of serial killer Leonard Lake, who would target, kidnap, rob and kill people - and even whole families. Sonia, the only survivor of Lake's killing spree, teams up with a private investigator to help him locate a woman who disappeared into Lake's compound. In the process, Sonia recounts the horrors of the house, where Lake and his accomplice would force her to videotape the killings.