Homicide detective John Hobbes witnesses the execution of serial killer Edgar Reese. Soon after the execution the killings start again, and they are very similar to Reese's style.

In the year 2035, convict James Cole reluctantly volunteers to be sent back in time to discover the origin of a deadly virus that wiped out nearly all of the earth's population and forced the survivors into underground communities. But when Cole is mistakenly sent to 1990 instead of 1996, he's arrested and locked up in a mental hospital. There he meets psychiatrist Dr. Kathryn Railly and the son of a famous virus expert who may hold the key to the Army of the 12 Monkeys; thought to be responsible for unleashing the killer disease.

When Mr. Deen discovers one of his students has been living out of his car and thrown into jail, he decides to bail him out. Determined to curb Nate’s self-destructive behavior, Deen quickly discovers a host of dark secrets slowly tearing Nate apart. What began as a good deed becomes a desperate fight to save Nate from his own demons. As Nate spirals deeper into despair, Deen must decide how far he’s willing to go to save a kid on the brink of losing everything—even himself.

Feisty ER nurse takes on the medical establishment when she uncovers an epidemic of misdiagnosis.