A man and a woman are on the run from gangsters whom he has stolen $12.5 million. When the gangsters show up, he takes them supposedly to where the money is hidden but instead leads them into a trap at a backwoods crystal-meth factory. The gangsters and the drug dealers start a shoot-out for unknown reasons and both go gunning for Belushi. Meanwhile an unscrupulous cop is secretly having an affair with the girl friend and planning to make off with the money.

A troubled psychiatrist goes in search of five schizophrenics who have escaped from a local mental institution. Infiltrating their makeshift mountain outpost, the doctor comes face to face with his own fears, limitations, and forsaken hopes as he becomes acquainted with the patients and their humorously poignant struggles.